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The effect of HTON treatment on synovial pannus with abnormal vascularization (CD34) and inflammatory phenotype of synoviocytes ( A ) and macrophages ( B ) in synovial tissue and corresponding quantitative analysis ( C ). P values were calculated by the two-tailed Student’s t test (*** P < 0.001). Data were presented as means ± SD. Scale bars 100 μm (A and B). DAPI, 4′,6-diamidino-2-phenylindole.

Journal: Science Advances

Article Title: NIR-photocatalytic regulation of arthritic synovial microenvironment

doi: 10.1126/sciadv.abq0959

Figure Lengend Snippet: The effect of HTON treatment on synovial pannus with abnormal vascularization (CD34) and inflammatory phenotype of synoviocytes ( A ) and macrophages ( B ) in synovial tissue and corresponding quantitative analysis ( C ). P values were calculated by the two-tailed Student’s t test (*** P < 0.001). Data were presented as means ± SD. Scale bars 100 μm (A and B). DAPI, 4′,6-diamidino-2-phenylindole.

Article Snippet: In addition, RAW264.7 macrophages were treated with lipopolysaccharide or/and hydrogen gas, and then intracellular ROS levels were detected with DCFH-DA (Beyotime Biotechnology), and their phenotypes were determined with antibodies against MMP-3 and CD206 (Abcam) and by the real-time PCR technique.

Techniques: Two Tailed Test